Nicotinamide with Cas 98-92-0

1.Improve skin barrier function

Niacinamide can promote the synthesis of ceramides in the skin, enhance the water locking ability of the stratum corneum, and reduce transdermal water loss. For patients with atopic dermatitis or dry skin, long-term use can alleviate flaking and tightness. Its mechanism is related to the activation of silk fibroin gene expression, but it needs to be continuously used for more than 8 weeks to take effect.

2.Regulating sebum secretion

Niacinamide has an improving effect on oily skin and mild to moderate acne by inhibiting sebaceous gland cell proliferation and triglyceride synthesis. Clinical data shows that its oil control effect is equivalent to 2% salicylic acid and does not cause skin sensitivity. Patients with seborrheic dermatitis should use antifungal drugs in combination.

3.Diminish pigmentation

Niacinamide can block the transfer of melanosomes to keratinocytes, with an effective rate of nearly 4% hydroquinone for melasma and post inflammatory pigmentation. Combined use with vitamin C can enhance antioxidant effects, but sensitive muscles need to establish tolerance from low concentrations. Pigmentation during pregnancy should be used under the guidance of a doctor.

4.Anti inflammatory

Niacinamide can alleviate the erythema symptoms of rosacea by inhibiting inflammatory factors such as tumor necrosis factor and interleukin. Its anti-inflammatory strength is equivalent to 1% clindamycin and is suitable for patients who cannot tolerate antibiotic treatment. When merging capillary dilation, pulsed dye laser treatment is required.

5.Adjuvant treatment for photosensitive skin diseases

Nicotinamide can repair UV induced DNA damage and reduce the incidence rate of actinic keratosis. Using under the guidance of professionals can reduce the recurrence rate of non melanoma skin cancer. Patients with systemic lupus erythematosus should evaluate liver and kidney function before use and avoid taking isoniazid tablets together.